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Disruptions to these processes or abnormalities in the participating enzymes can silence tumor suppressor genes [26, 27]

Microbiota-based interventions have been shown to induce behavioral changes in ASD animal models, with metabolic modulation emerging as a primary pathway through which the gut microbiota exerts its influence on the CNS

Psychiatry 43 HoffmannA.ZillerM.SpenglerD

Nevertheless, methotrexate has considerable adverse effects, particularly hepatotoxicity, which necessitates regular monitoring of liver function and adaptations to the dosage based on patient tolerance (Barnhill et al